Voltammetric behaviour of brodimoprim at mercury and its determination in biological fluids using differential-pulse polarography
نویسنده
چکیده
A differential-pulse polarographic (DPP) method was developed for the determination of brodimoprim (BDP) in Michaelis (MCL) buffer. The peak potential (Ep) occurs at 21.33 V (versus SCE) when the pH of the system is 4.0. The voltammetric behaviour in MCL buffer and the mechanisms of the electrode reaction were studied by, e.g., linear sweep voltammetry, cyclic voltammetry and normal-pulse polarography. The wave was confirmed to be an irreversible adsorptive wave. The relationship between peak height and concentration of BDP was linear in the range 5.0 3 1028–1.0 3 1027 mol l21 with a detection limit of 1.0 3 1029 mol l21, when the adsorptive accumulation time was 5 min.
منابع مشابه
Extractive Differential Pulse Polarography of Mo (VI) Oxinate in Chloroform and its Application in the Determination of Molybdenum in Steel
The voltammetric characteristics of Mo (VI) oxinate at the mercury electrode, in the presence of tri-butylammonium perchlorate (tri-BAP) and piperidinium perchlorate (PP) + piperidine (P) as two different types supporting electrolytes, have been studied in chloroform. With the both supporting electrolytes a two electron irreversible process for the reduction of Mo (VI) oxinate was observe...
متن کاملSelective Determination of Trace-Bismuth by Extraction-Differential Pulse Polarography in Non-Aqueous Media
The voltammetric characteristics of bismuth(III)-oxinate in chloroform at the mercury electrode were investigated and a quasi-reversible behavior for Bi(III) oxinate reduction was confirmed. Preceded by the extraction of Bi(III) oxinate in chloroform, differential pulse polarography was developed in the extracts for determination of the trace-bismuth. The linear range of the calibration gra...
متن کاملDifferential Pulse Polarographic Determination of Trace Antimony in Standard Biological Samples after Preconcentration Using 2-Nitroso-1-naphthol-4-sulfonic Acid
A highly selective, sensitive, rapid and economical differential pulse polarographic method has been developed for the determination of trace amounts of antimony in various standard alloys and biological samples after adsorption of its 2-nitroso-1-naphthol-4-sulfonic acid - tetradecyldimethylbenzylammonium chloride on microcrystalline naphthalene in the pH range of 7.5-11.0. After filtratio...
متن کاملSimultaneous Voltammetric Determination of Nitazoxanide and Ofloxacin in Pharmaceutical Formulation
A simple, sensitive and highly selective electrochemical method was developed for the simultaneous determination of nitazoxanide and ofloxacin in aqueous media (Britton-Robinson buffer, pH-8.36) on a hanging mercury drop electrode (HMDE) using differential pulse polarography (DPP). Using DPP a separation of about 936 mV between the peak oxidation potentials of nitazoxanide and ofloxacin present...
متن کاملThe voltammetric study and determination of ramipril in dosage forms and biological fluids.
The voltammetric behavior of ramipril was studied using cyclic voltammetry, direct current polarography (DCt), differential pulse polarography (DPP) and alternating current polarography (ACt). Ramipril developed well-defined cathodic waves in Britton-Robinson buffers over the pH range 6-12. The waves were characterized as being diffusion-controlled, irreversible and partially affected by adsorp...
متن کامل